Reinitz´s talk highlights (Session 5)
After a short recapitulation of the development of the early Drosophila embryo, Reinitz showed us how to use the entire embryo to build a quantitative model of the transcriptional network at a cellular resolution. Reinitz´s talk focused on a single node, “eve”, rather than in the whole transcriptional network in the early Drosophila embryo. “eve” is a major regulator during the blastoderm development in terms of the number of genes that are controlled by it. The predictive power of the model built by his group has made possible a variety of applications in the fields of genomic evolution and synthetic biology.
In the last part of his talk, Reinitz introduced the concept of decanalization of gene expression. Based in de concept of canalization of development introduced by Waddington in 1942 and using his transcriptional network model, Reinitz showed how the model is able to predict the existence of mutants, Kr-, displaying qualitatively altered and decanalized gene expression.