James Briscoe´s talk highlights (Session 5)

Briscoe300Due to confidentiality issues we cannot include a summary of James Briscoe´s talk. Find the abstract published in the Conference Book below:


“Gradients of diffusible signals, normally referred to as morphogens, govern patterns of gene expression in many developing tissues. In the vertebrate neural tube, for example, molecularly distinct domains of progenitors that generate different neuronal subtypes are arrayed along the dorsal-ventral axis. We are particularly interested in the ventral part of the neural tube, which generates the motor neurons and interneurons that coordinate motor output. Here pattern formation is governed by the morphogen Sonic Hedgehog (Shh). We have found that both the concentration and duration of Shh signalling contributes to pattern formation by regulating a set of downstream transcription factors. The design of the transcriptional network integrates the activity of the morphogen effectors with uniformly expressed and differentially regulated transcription factors and is responsible for the spatial-temporal patterns of gene expression. In addition, the network renders cells insensitive to fluctuations in signaling and confers hysteresis – memory of the signal. Together, the interplay between the input by Shh and the transcriptional network of recipient progenitor cells explain the stereotyped and precise patterning of the developing neural tube.”

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